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Standard Practice for Testing Materials in Rabbits for Primary Skin Irritation
ASTM F719-20
Organization:
ASTM - ASTM International
Year: 2025
Abstract: 4.1 Materials that are to be in contact with the skin should not cause irritation to the skin. Since it is probably the substances leached from a material that cause the irritation, this practice provides for direct material-skin contact testing or for skin exposure to the liquid extract of the test material. The rationale for this rabbit test is that it is a comparatively quick and sensitive method which, through use over the years, has become a generally accepted method. Additionally, the albino rabbit allows for easy visualization of erythema and edema, which are the cardinal signs of skin irritation.
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Standard Practice for Testing Materials in Rabbits for Primary Skin Irritation
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| contributor author | ASTM - ASTM International | |
| date accessioned | 2025-09-30T19:19:04Z | |
| date available | 2025-09-30T19:19:04Z | |
| date copyright | 2025 | |
| date issued | 2025 | |
| identifier other | f0719-20r25.pdf | |
| identifier uri | https://yse.yabesh.ir/std/handle/yse/342794 | |
| description abstract | 4.1 Materials that are to be in contact with the skin should not cause irritation to the skin. Since it is probably the substances leached from a material that cause the irritation, this practice provides for direct material-skin contact testing or for skin exposure to the liquid extract of the test material. The rationale for this rabbit test is that it is a comparatively quick and sensitive method which, through use over the years, has become a generally accepted method. Additionally, the albino rabbit allows for easy visualization of erythema and edema, which are the cardinal signs of skin irritation. | |
| language | English | |
| title | Standard Practice for Testing Materials in Rabbits for Primary Skin Irritation | en |
| title | ASTM F719-20 | num |
| type | standard | |
| status | Active | |
| tree | ASTM - ASTM International:;2025 | |
| contenttype | fulltext | |
| scope | 1.1 This practice covers a procedure by which the irritancy of a material may be assessed through contact with abraded and intact skin of rabbits. 1.2 The results of this practice depend upon the effectiveness with which contact between the skin and the test material is established and maintained. Because of the operator technique included in performing this test, it is important that the test be performed by personnel with appropriate training. 1.3 The values stated in SI units are to be regarded as standard. No other units of measurement are included in this standard. 1.4 This standard may involve hazardous materials, operations, and equipment. This standard does not purport to address all of the safety concerns, if any, associated with its use. It is the responsibility of the user of this standard to establish appropriate safety, health, and environmental practices and determine the applicability of regulatory limitations prior to use. 1.5 This international standard was developed in accordance with internationally recognized principles on standardization established in the Decision on Principles for the Development of International Standards, Guides and Recommendations issued by the World Trade Organization Technical Barriers to Trade (TBT) Committee. | |
| identifier DOI | 10.1520/F0719-20R25 |